In this framework, Veltha will play an essential role in the design of a Regional Systemic Circular Economy Approach. We will develop a circular economy monitoring system through the provision of methodologies and toolkits to support the regional transition. We will define strategies for the creation of new circular business models and regional enhancements, alongside generating and assessing impact through citizens and stakeholders’ engagement for CSSs deployment. We will then explore replication strategies to broaden the regional approach and enhance the reiteration potential to extend the systemic solution to other fellow regions.